Home Print this page Email this page Users Online: 332
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2022  |  Volume : 12  |  Issue : 2  |  Page : 158-167

Evaluation of genotoxicity induced by endodontic materials: A systematic review

Department of Conservative Dentistry and Endodontics, AMU, Aligarh, Uttar Pradesh, India

Correspondence Address:
Dr. Huma Iftekhar
Department of Conservative Dentistry and Endodontics, AMU, Aligarh, Uttar Pradesh
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sej.sej_163_21

Rights and Permissions

The ability of a substance to cause harm to the DNA molecule is known as genotoxicity. Because there is significant evidence of link between genetic damage and carcinogenesis, determining the real health hazards to patients and dental workers requires a thorough examination of genotoxicity caused by various dental materials. The aim of this paper is to provide a thorough overview of the genotoxicity induced by various endodontic materials. A systematic electronic search and screening of reference list were undertaken until November 2019. A meticulous search confined to English language articles was carried out in PubMed, Web of Science, and Scopus databases from their inception. The electronic search method retrieved 338 papers after the removal of duplicates, only 25 papers met the inclusion requirements following a thorough review of the findings. All evidence of genotoxicity has been found in the literature notably in relation to bleaching agents, restorative materials, and resin-based sealers. Such data will definitely be included to that already established for regulatory purposes as a secure way to enhance oral healthcare and avoid oral carcinogenesis. Reported information of genotoxicity induced by various endodontic materials is crucial for validating their safety in clinical practice as well as for identifying potential gaps in knowledge that must be studied further in future studies.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded140    
    Comments [Add]    

Recommend this journal